マルチカラムシステムによる逆相液体クロマトグラフィーの工業化

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  • Industrial-scale reversed-phase liquid chromatography with a multicolumn system.
  • マルチ カラム システム ニ ヨル ギャクソウ エキタイ クロマトグラフィー

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An industrial-scale reversed-phase liquid chromatograph was developed by using a multicolumn system. Its use reduced the volume of solvent and the operation time for chromatography, to about one -tenth of those required in a conventional elution. As a result, the maximum concentration of the objective component increased approximately fifteen times.<BR>A simulation method was used to optimize the operational conditions of the column system. The validity of the calculated result was confirmed experimentally.<BR>In industrial-scale liquid chromatography the multicolumn system effectively increases the efficiency of the whole purification process.

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