Entrapment of Water Soluble Material into Biodegradable Microcapsule Prepared by Solvent Evaporation.

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  • KIYOYAMA SHIRO
    Department of Chemical Science and Enginieering, Miyakonojo National College of Technology
  • SHIOMORI KOICHIRO
    Department of Materials Science, Miyazaki University
  • KAWANO YOSHINOBU
    Department of Materials Science, Miyazaki University
  • HATATE YASUO
    Department of Applied Chemistry and Chemical Engineering, Faculty of Engineering, Kagoshima University

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  • （Ｗ／Ｏ／Ｗ）複合エマルションの液中乾燥法による生分解性マイクロカプセルへの水溶性芯物質の内包特性
  • WOW フクゴウ エマルション ノ エキチュウ カンソウホウ ニヨル セイブン

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Abstract

Preparation of biodegradable microcapsule using a poly lactic acid as wall material was performed by (W/O/W) emulsion solvent evaporation method. Fractional entrapment of the core material and the average diameter of the microcapsule are independent of the composition of the inner aqueous phase, such as salt concentration, pH and viscosity. On the other hand, by changing the salt concentration of the outer aqueous phase and the hold up of dispersion phase in the (W/O) emulsion, it is possible to increase the fractional entrapment of the core material with the increase in (W/O/W) emulsion stability and amount of wall material. The entmpment effect is controlled by preparation conditions.

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