Biomedical Engineering. Development of Novel Magnetic Sensing for Brain Lesion Using Functional Magnetic Particles.

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  • SHINKAI MASASHIGE
    Department of Biotechnology, Graduate School of Engineering, Nagoya University
  • OHSHIMA AKIRA
    Department of Biotechnology, Graduate School of Engineering, Nagoya University
  • YANASE MITSUGU
    Department of Biotechnology, Graduate School of Engineering, Nagoya University
  • UCHIYAMA TSUYOSHI
    Department of Electronics, Graduate School of Engineering, Nagoya University
  • MOHRI KANEO
    Department of Electronics, Graduate School of Engineering, Nagoya University
  • WAKABAYASHI TOSHIHIKO
    Department of Neurosurgery, School of Medicine, Nagoya University
  • YOSHIDA JUN
    Department of Neurosurgery, School of Medicine, Nagoya University
  • HONDA HIROYUKI
    Department of Biotechnology, Graduate School of Engineering, Nagoya University
  • KOBAYASHI TAKESHI
    Department of Biotechnology, Graduate School of Engineering, Nagoya University

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Other Title
  • バイオメディカル　　機能性磁性微粒子を用いた脳病変部に対する新しい磁気センシング法の開発
  • キノウセイ ジセイ ビリュウシ オ モチイタ ノウ ビョウヘンブ ニ タイスル

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Abstract

Real-time sensing of a brain lesion under operation on the brain is investigated. We selected a combination of the functional magnetic particles and small and high sensitive magnetic sensor, the magneto-impedance (MI) sensor, for the sensing method. At first, we detected a magnetic field of an agarose gel containing magnetite particles using the MI sensor. It was found that a magnetization of the magnetite by a static magnetic field is necessary for the detection. We also tried to detect the magnetite particles in a rat tumor which was transplanted under the skin of the rat leg. The magnetite cationic liposomes, at which the magnetite particles were coated with a cationic lipid and phospholipids membrane, were directly injected in the tumor and magnetized by the static magnetic field generator at 1.8 T. By using the MI sensor, the magnetic field distribution of the MCL was detected, and its distribution indicated that the MCL is localized in the tumor.

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