Effect of Column Number in Ion Exchange Multicolumn System for L-Lysine Purification

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  • Nagai Hidetada
    Isolation & Purification Technology Laboratory, Fermentation & Biotechnology Laboratories, Ajinomoto Co. Inc.
  • Kuwabara Ko
    Isolation & Purification Technology Laboratory, Fermentation & Biotechnology Laboratories, Ajinomoto Co. Inc.
  • Carta Giorgio
    Department of Chemical Engineering, University of Virginia

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Other Title
  • Ｌ－リジン精製イオン交換樹脂多塔システムにおける塔数の影響
  • L リジン セイセイ イオン コウカン ジュシ タトウ システム ニ オケル トウスウ ノ エイキョウ

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A simulation model describing L-lysine behavior in multicolumn cation exchange separation was developed and used to investigate the effect of column number in adsorption and desorption of counter-current multicolumn systems.<br>DIAION SK-1B was used as an example of cation exchange resin, which has 8% of DVB content. L-lysine dissociation constants, ion exchange equilibrium constants and intraparticle diffusivities were measured at 25°C. These fundamental parameters were applied for multicolumn simulation. All calculated results were obtained for a column of 1.5 cmφ×10 cm and switching time of 3600 s.<br>1. In the case of single-column adsorption, L-lysine leakage in the adsorption train was observed at a feed rate of 5.7×10−2 mol/h of L-lysine when monovalent lysine solution was fed to the multicolumn system. Two- and three-column adsorption systems showed L-lysine leakage at feed rates of 1.2×10−1 mol/h and 1.4×10−1 mol/h of L-lysine, respectively. Thus, the increase of column number from 1 to 2 was effective for prevention of the leakage, while the increase of column number from 2 to 3 was not effective.<br>2. In the case of single-column elution, L-lysine was not completely desorbed at any feed rate of ammonia into the system. Two- and three-column desorption systems showed similar results, with complete L-lysine desorption at feed rates of 6.6×10−2 mol/h and 1.0×10−1 mol/h of ammonia, respectively.

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