書誌事項
- タイトル別名
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- Biomedical Engineering. Relationship between Blood Compatibility and Nonthrombogenic Polymer Surfaces.
- コウ ケッセンセイ ザイリョウ ニ オケル ケツエキ ザイリョウ カイメン
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抄録
Hypotheses proposed to design nonthrombogenic polymer surfaces include, 1) phase-separated microdomain surfaces, 2) hydrophilic surfaces, 3) bioactive molecule incorporated surfaces and 4) biomembrane-like surfaces. In order to clarify the relationship between these surface design and their blood compatibility, we evaluated platelet adhesion and complement activation on these surfaces using an epifluorescent video microscopy (EVM) system, and analyzed adsorbed proteins on these surfaces using a sheep chronic left ventricular assist device (LVAD) model. The results are as follows ; 1) thrombogenesis depends on the amount of adhered platelet at the initial contact with blood on the surfaces, 2) nonthrombogenicity of the blood contacting surfaces is dependent on the thickness, conformation and components of adsorbed proteins on the surfaces and 3) complement activation is not correlated with the amount of adhered platelet.
収録刊行物
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- 化学工学論文集
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化学工学論文集 24 (2), 217-221, 1998
公益社団法人 化学工学会
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詳細情報 詳細情報について
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- CRID
- 1390282679486361984
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- NII論文ID
- 10002835263
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- NII書誌ID
- AN00037234
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- ISSN
- 13499203
- 0386216X
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- NDL書誌ID
- 4424751
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
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- 抄録ライセンスフラグ
- 使用不可