書誌事項
- タイトル別名
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- Application of Submicron-sized Binder Particles in Dry Granulation Using a Roller Compactor and Its Evaluation
- ローラーコンパクター オ モチイタ カンシキゾウリュウ ニ オケル サブミクロン ケツゴウザイ リュウシ ノ オウヨウ ト ソノ ヒョウカ
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説明
<p>The method to improve the properties of dry granules was investigated by introducing pre-coating process with an active pharmaceutical ingredient (API) and a submicron-sized binder prior to conventional roller compaction. Hydroxypropylcellulose (HPC) and acetaminophen (APAP) were used as models of a binder and a low-compactible API, respectively. The submicron-sized HPC (HPC-subMP) was obtained by a lab-scale spray dryer. The APAP particles were pre-coated with 5–10% of the HPC-subMP by a high shear mixer, formed into granules using a lab-scale roller compactor, mixed with other excipients and then compressed to make them tablets containing 50% APAP. The tablets prepared with the HPC-subMP showed a high tensile strength without significant retardation of the disintegration time in comparison to those with a raw HPC particle, indicating that the use of API particles pre-coated with submicron-sized binder particles in roller compaction was effective to prepare granules suitable for tableting without any fundamental changes of materials and manufacturing processes.</p>
収録刊行物
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- 粉体工学会誌
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粉体工学会誌 55 (1), 4-12, 2018
一般社団法人 粉体工学会
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詳細情報 詳細情報について
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- CRID
- 1390282679488594432
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- NII論文ID
- 130006338351
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- NII書誌ID
- AN00222757
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- ISSN
- 18837239
- 03866157
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- NDL書誌ID
- 028781267
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDLサーチ
- Crossref
- CiNii Articles
- OpenAIRE
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- 抄録ライセンスフラグ
- 使用不可
