７１‐及び８１‐ヘリックスアミロース包接化合物中におけるサリチル酸の分子状態の評価

森部 久仁一, 東 顕二郎, 戸塚 裕一, 山本 恵司

doi:10.4164/sptj.43.633

７１‐及び８１‐ヘリックスアミロース包接化合物中におけるサリチル酸の分子状態の評価

DOI 被引用文献1件オープンアクセス

森部久仁一

千葉大学大学院薬学研究院
東顕二郎

千葉大学大学院薬学研究院
戸塚裕一

千葉大学大学院薬学研究院
山本恵司

千葉大学大学院薬学研究院

書誌事項

タイトル別名

Evaluation of Molecular States of Salicylic Acid in 71- and 81- Amylose Complexes

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説明

Molecular states of salicylic acid (SA) in amylose complexes prepared by sealed-heating were investigated. The powder X-ray diffraction patterns revealed the possibility of the inclusion formation due to the structural change in amylose from a 6₁-helix, which designates six glucose units per helical turn, to a 7₁-helix and an 8₁-helix depending on the concentration of guest molecules. Carbon thirteen solid state cross-polarization and magic angle spinning NMR spectra showed that the molecular states of SA in the 7₁-helix and 8₁-helix amylose complexes were similar to those in β-cyclodextrin (CD) and γ-CD inclusion complexes, respectively. It was concluded that one SA molecule was included in the cavity of one unit of amylose helix for the 7₁-helix amylose complex and two SA molecules for the 8₁-helix amylose complex.