Evaluation of Pharmaceutical Glidant with Atomic Force Microscope and Mechanism of Flowability Enhancement

DOI 2 Citations Open Access
  • Machida Ohta Kotoe
    Department of Pharmaceutical Research, Nippon Boehringer Ingelheim Co., Ltd.
  • Toyoshima Kenzo
    Department of Pharmaceutical Research, Nippon Boehringer Ingelheim Co., Ltd.
  • Fuji Masayoshi
    Ceramics Research Laboratory, Nagoya Institute of Technology
  • Takei Takashi
    Department of Applied Chemistry, Graduate School of Engineering, Tokyo Metropolitan University
  • Chikazawa Masatoshi
    Department of Applied Chemistry, Graduate School of Engineering, Tokyo Metropolitan University

Bibliographic Information

Other Title
  • ＡＦＭを用いた医薬品流動化剤の物性評価と流動性改善効果の発現メカニズム

Description

The effect of geometric surface structure of glidant on flowability of pharmaceutical fillers and the factors that determine the optimum amount of glidant added were investigated with AFM and IR spectroscopy. Several types of silica particles were used as a glidant in preparing the mixture of lactose and microcrystalline cellulose. The flowability of mixed powder was evaluated with Can's index. As a result, it was found that the flowability and the optimum mixing ratio depend on the geometric surface structure of glidant. AFM study showed that the porosity of silica particles plays an important role in determining flowability through the reduction in adhesion force. Furthermore, IR study suggested that the optimum mixing ratio is closely related to the surface coverage of filler with glidant. The optimum mixing ratio of porous silica is smaller than that of nonporous silica since the surface coating with porous silica is completed at a lower mixing ratio.

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Details 詳細情報について

  • CRID
    1390282679489234176
  • NII Article ID
    130003952628
  • DOI
    10.4164/sptj.41.169
  • COI
    1:CAS:528:DC%2BD2cXivVaiurc%3D
  • ISSN
    18837239
    03866157
    http://id.crossref.org/issn/03866157
  • Text Lang
    ja
  • Data Source
    • JaLC
    • Crossref
    • CiNii Articles
    • OpenAIRE
  • Abstract License Flag
    Disallowed

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