Alveolar Macrophage Targeted Nano-DDS for Inhalation Therapy of Tuberculosis

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  • 肺胞マクロファージを標的とした結核治療のための経肺投与ナノ DDS
  • ハイホウマクロファージ オ ヒョウテキ ト シタ ケッカク チリョウ ノ タメ ノ ケイ ハイ トウヨ ナノ DDS

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Abstract

We prepared rifampicin （RFP）/poly （lactic-co-glycolic acid） （PLGA） nanoparticle-containing mannitol （MAN） microspheres for inhalation therapy of tuberculosis using a four-fluid nozzle spray drier in one step. The uptake of RFP by alveolar macrophages in the lungs of rats from the RFP/PLGA microspheres was very small. The uptake of RFP from the RFP/PLGA nanoparticles, however, was larger because the nano-sized PLGA particles could be retained in the deeper part of the lungs. This study shows that it is feasible to prepare RFP/PLGA nanoparticle-containing microspheres using a four-fluid nozzle spray drier in one step, and that the particles are retained in the lungs for prolonged periods and targeted to alveolar macrophages.

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