Dry Surface Modification of Adhesive Fine Particle by a Horizontal Shear Mixer with Super High Speed Chopper

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  • Asai Naochika
    Development Department, DALTON CORPORATION
  • Nakamura Hideya
    Department of Chemical Engineering, Graduate School of Engineering, Osaka Prefecture University
  • Watano Satoru
    Department of Chemical Engineering, Graduate School of Engineering, Osaka Prefecture University

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Other Title
  • 超高速チョッパーを有する水平型撹拌混合機を用いた付着性微粒子の乾式表面改質
  • チョウコウソク チョッパー オ ユウスル スイヘイガタ カクハン コンゴウキ オ モチイタ フチャクセイ ビリュウシ ノ カンシキ ヒョウメン カイシツ

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Abstract

Improvement of flowability and dissolution property of particles was conducted by a dry surface modification using a novel shear mixer with a super high speed chopper (SPM mixer). Corn starch and ibuprofen were treated with silica under various rotation speeds and operation time. The flowability was evaluated by an angle of repose and dissolution property was evaluated by a dissolution test according to the Japanese Pharmacopoeia. <br>It was found that composite particles with good flowability were obtained within 1 minute treatment time. And it was implied that the faster rotation speed of chopper resulted in the shorter treatment time.<br>In the SPM mixer, surface modification and grinding were progressed simultaneously. Within 1 minute treat time, the particle size was smaller and dissolution velocity was faster by an increase of rotation speed of chopper. And composite particles with superior flowability obtained.

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