Nano Particle as Artificial Food Additive Influence to Intestinal Bacterial Flora

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  • Tokumoto Hayato
    Department of Chemical Engineering, Osaka Prefecture University
  • Nomura Toshiyuki
    Department of Chemical Engineering, Osaka Prefecture University
  • Hoshi Hideyuki
    Graduate School of Humanities and Sustainable System Sciences, Osaka Prefecture University
  • Nii Yasutaka
    Department of Chemical Engineering, Osaka Prefecture University
  • Ootani Toshiharu
    Department of Chemical Engineering, Osaka Prefecture University
  • Nomoto Kenta
    Department of Chemical Engineering, Osaka Prefecture University

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Other Title
  • 食品添加物粒子が腸内細菌叢に与える影響
  • ショクヒン テンカブツ リュウシ ガ チョウ ナイ サイキンソウ ニ アタエル エイキョウ

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Abstract

<p>Particles of additives that are ingested along with food can either adhere to the intestinal microflora or be absorbed, and these may possibly lead to illnesses caused by changes in the microflora composition. Barely 1% of Fe2O3 particles dissolve in acids present in the stomach. In addition, the direct administration of Fe2O3 particles into the stomach with a probe showed no adverse health effects. However, mixing Fe2O3 particles of a smaller diameter into food and orally administering the dose over a period of more than 2 weeks encouraged the multiplication of the diarrhea-causing Clostridium family amongst intestinal flora, indicating the cause of the diarrhea outbreak. On the other hand, multiplication of the Clostridium species was suppressed by the multiplication of another family within the intestinal flora, namely Lactobacillus. It was confirmed that by analyzing the formation of fermentation products such as hydrogen, acetic acid, and lactic acid, symptoms of diarrhea caused by the alteration of intestinal microflora composition spontaneously recovered.</p>

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