Investigations on EL mouse Up to Date

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  • Suzuki Jiro
    Sannou Institute of Psychiatry and Psychology, Medical Corporation Nozomi, Rinsen Clinic

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  • 現在までのELマウス研究

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<p>In this article, the studies on EL mouse as an model of epilepsy carried out in our laboratory since the preceding review by the author was published in 2003 are described. Experimental animals were EL and DDY (or few ddN) mice. Using the microelectrodes the activities of the parietal cortex (PCX) neurons were found extremely larval at the resting state but explosively active during the seizure state. In the PCX and Hippocampus remarkably abnormal activities of GABA system and DNA and/or other substances were found at the molecular level. A new therapeutic direction of seizures and abnormal behaviors of epilepsy were suggested by transplantation of cultured neural stem cells. The hereditary mode of the EL mouse is the autosomal dominant, but its seizure itself may provoke an epigenetic phenomenon.</p>

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