成人および小児の難治てんかんに対するＺｏｎｉｓａｍｉｄｅの使用経験　１年以上継続投与している３５例について

DOI
  • 金澤 治
    国立療養所宇多野病院 (関西てんかんセンター) 小児科
  • 兼本 浩祐
    国立療養所宇多野病院 (関西てんかんセンター) 精神科
  • 扇谷 明
    国立療養所宇多野病院 (関西てんかんセンター) 小児科
  • 河合 逸雄
    国立療養所宇多野病院 (関西てんかんセンター) 小児科

書誌事項

タイトル別名
  • A clinical trial of zonisamide on adults and children with refractory epilepsy. Thirtyfive cases with a long administration for more than one year.
  • Thirtyfive Cases with a Long Administration for More than One Year
  • 1年以上継続投与している35例について

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抄録

There have been some reports about the efficacy of the new antiepileptic drug, zonisamide, during recent several years. According to those reports, various types of refractory epileptic seizures respond to the administration of the new drug. However, they usually report only about short term administration of the drug.<BR>Thirty-five patients including children who had been administered zonisamide for more than one year are reported.<BR>Seven of them (20%) have been free from epileptic seizures for more than six months. On the other hand, eight of them (23%) showed only transient improvement, suggesting the development of tolerance to the drug. Most cases showed improvement from one week to several months after the administration. Because maximum effects appeared several years later in some patients, continuation of administration of the drug was considered to be important.The effective range of the plasma level of the drug was 4.1-46.3Junzou Shiraishi, g/ml and the effective dose was 2.4-17.5mg/kg.<BR>All side effects were mild and transient.<BR>Zonisamide is considered to be a safe antiepileptic drug with broad -spectrum of effects on refractory epilepsy.

収録刊行物

  • てんかん研究

    てんかん研究 8 (1), 29-38, 1990

    一般社団法人 日本てんかん学会

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