A lensless digital enzyme-linked immunosorbent assay (ELISA) system using a CMOS image sensor for fluorescence detection

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  • 蛍光検出CMOSイメージセンサを用いたレンズレスデジタルELISAシステム(固体撮像技術および一般)
  • 蛍光検出CMOSイメージセンサを用いたレンズレスデジタルELISAシステム
  • ケイコウ ケンシュツ CMOS イメージセンサ オ モチイタ レンズレスデジタル ELISA システム

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Abstract

Enzyme-linked immunosorbent assay(ELISA) is a diagnosis method which is used for detecting viruses or tumor markers. A combination of antigen-antibody reactions and fluorescent reactions are utilized in ELISA. Recently, digital ELISA has been proposed to achieve higher sensitivity. We have been developing compact digital ELISA system by replacing a fluorescent microscope with a CMOS image sensor as a fluorescence detection tool. In this report, stacked photodiode CMOS image sensor for discriminating fluorescence from excitation light is proposed. A light pipe array filled with absorption filter which has high fluorescence coupling efficiency is also described.

Journal

  • ITE Technical Report

    ITE Technical Report 39.16 (0), 33-36, 2015

    The Institute of Image Information and Television Engineers

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