Usefulness of standard values of salivary and urinary cortisol concentrations in workers established by high performance liquid chromatography.

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  • 就労者の唾液中・尿中コルチゾール標準値作成の試みとその有用性の検討　　高速液体クロマトグラフィーを用いて
  • シュウロウシャ ノ ダエキ チュウ ニョウ チュウ コルチゾール ヒョウジュンチ サクセイ ノ ココロミ ト ソノ ユウヨウセイ ノ ケントウ コウソク エキタイ クロマトグラフィー オ モチイテ
  • 高速液体クロマトグラフィーを用いて

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The objective of the present study was to establish standard values for the salivary and urinary cortisol concentrations, since cortisol levels are often used as stress indicators. Saliva and urine samples were collected from 85 men and 81 women, between the ages of 20-59 years, at five different times (when they got out of bed, 10:00, 11:40, 14:00 and 16:00) on two different days (one workday and one holiday). Cortisol concentrations were determined by the HPLC method, and standard values (mean±S.D.) were calculated in relation to sex, measurement time and day. In addition, the concentration of cortisol in 299 saliva samples and 155 urine samples was determined by the RIA method to derive a simple equation to compare the RIA and HPLC methods. Under transient stress, the level of salivary cortisol deviated greatly from the standard value, suggesting that the present standard values are useful in assessing stress. Finally, the scope of application of standard value tables was discussed.

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