On the Antibiotic Action of Unsaturated Ketones

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Other Title
  • 不飽和ケトンの抗生作用に關する研究
  • フホウワ ケトン ノ コウセイ サヨウ ニ カンスル ケンキュウ 1 ハロゲンカ フホウワ ケトン
  • Part 1. Unsaturated Halogenated Ketones. (1)
  • (第1報)ハロゲン化不飽和ケトン (1)

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Description

The antibiotic activities of 2, 4, 4, 6, 6-pentachlorocyclohexene (1) dione (3, 5) (PeM) and seven of its related compounds were tested, and the antibiotically active radicals in the constitutions of these compounds were traced. PeM had a strong antibiotic activity against the following microörganisms: Asp ergillus glaucus at dil. 1:300, 000, Penicillium roqueforti at dil. 1:300, 000, Mycoderma sp. at dil. 1:100, 000, Saccharomyces cerevisiae at dil. 1:100, 000, Escherichia coli at dil. 1 100, 000, and Bacillus subtilis at dil. 1:100, 000 in vitro.<br> From the results obtained, it may be said that not only chlorine atoms but also carbonyl groups of PeM were responsible for antibiotic activities.

Journal

  • Nippon Nōgeikagaku Kaishi

    Nippon Nōgeikagaku Kaishi 26 (2), 61-64, 1952

    Japan Society for Bioscience, Biotechnology, and Agrochemistry

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