Effect of Tonifying Kidney using Chinese Medicine(Guzhen Recipe) to Retard Aging of the Hippocampus and Hypothalamus-Pituitary-Adrenal-Thymic(HPAT) Axis in Senile Rat.

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  • CHAO Weikang
    Dept.of Biochemistry, Shanhai University of Traditional Chinese Medicine, Shanhai, China
  • JIN Guoqin
    Dept.of Biochemistry, Shanhai University of Traditional Chinese Medicine, Shanhai, China
  • LI Wen
    Dept.of Biochemistry, Shanhai University of Traditional Chinese Medicine, Shanhai, China
  • WANG Cai Yuan
    Kansai College of Acupucture Medicine

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Other Title
  • 固真処方の老年ラットに対する影響　海馬，下丘脳，下垂体，腎上腺，胸腺軸における作用について
  • コシン ショホウ ノ ロウネン ラット ニ タイスル エイキョウ カイバ カ
  • Aging of the Hippocampus and Hypothalamus-Pituitary-Adrenal-Thymic (HPAT) Axis in Senile Rat
  • 海馬、下丘脳、下垂体、腎上腺、胸腺軸における作用について

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Abstract

According to the TCM theory, human growth, development and aging are closely related to kidney function and the main cause of human senility is deficiency of “kidney essence”. Recent studies showed that the “kidney” in TOM include the regulatory function of the neuroendocrine and immune systems.<BR>In this paper, the effect of Guzhen Recipe (_??__??__??_), an aging retarding prescription composed of kidney tonifying herbs such as Radix Polygoni Multiflori (_??__??_), Herba Cistanchis (_??__??_) Rubus Chiagii (_??__??__??_) etc. on the hippocampus and HPAT axis in senile rats were observed. The results showed : (1) With age the number of glucocorticoid receptors (GCR) in the hippocampus, the concentrations of NE, DA, 5-HT in the hypothalamus were markedly decreased, while the plasma corticosterone concentration in senile rats was obviously increased. (2) The thymocyte GCR nuclear transition rate was increased significantly ; (3) The contents of cytoplasmic protein, nuclear RNA and DNA, the thymus weight/body weight ratio, the serum thymic factors as well asthe rate of lymphocyte transformation, the activity of IL-2 and NK cells in senile rats were obviously decreased compared to those of young control rats. Guzhen recipe however, was capable of improving these changes in the neuroendocrine-thymic net work in senile rats to varying degrees, suggesting that the kidney with Chinese Medicine might retard the functional degeneration of thymic endocrine partly by improving the feedback regulation of the hippocampal GCR and increasing the concentrations of NE and 5-HT of hypothalamus, thus decreasing the plasma corticosterone ; Simultaneously weakening the nuclear transition rate of thymocyte GCR, which in turn improving the immune function of the senile animal.<BR>We concluded that Guzhen Recipe may retard the functional degeneration of both the hypo-thalamuspituitary-gornadal-thymic and hypothalamus-pituitary-thyroidal-thymic axis. All the above results revealed that retarding the aging effect using TCM in volves multiple-leves, multiple-systems and links. Using holistic regulation, imbalance links in aging process are modulated and the equilibrium of Yin and Yang are maintained. This is an important characteristic of the TCM to retard aging.<BR>This research was supported by funds from National Natural Science Foundation of China No. 38970908.

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