書誌事項
- タイトル別名
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- Sleep disturbances in children with congenital and acquired hypothyroidism.
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説明
We studied the sleep development of 3 hypothyroid children. Sleep-wakefulness circadian rhythm was recorded day by day in all cases. Four serial polysomnographical recordings (PSG) before and after the treatment were performed in Case 1, a hypothyroid girl detected by neonatal screening. We also executed PSGs before treatment in Case 2, a four-year-old girl of dwarfism caused by ectopic hypoplasia of thyroid gland and Case 3, a twelve-year-old girl of chronic thyroiditis. Circadian rhythm of Case 1 was not severely disturbed. But she showed a decrease of the sleep stage of rapid eye movements (SREM) at 1 month and 5 months. That became normalized with her growing. Other two cases exhibited no abnormalities in the circadian rhythm and in proportions of sleep stages.<BR>Body movements during sleep (BMs) and rapid eye movements during SREM (REMs) were evaluated. Gross movements (GMs) were defined as BMs involving trunk lasting more than two seconds and twitch movements (TMs) as brief EMG activities lasting 0.5 seconds or less. In Case 1 GMs in stage 1 sleep (SI) decreased at 1 month, and also TMs in SI, SREM and the total sleep (TS) at 1 month and 2 years. REMs in the latter half of sleep were also reduced before 1 year, increasing gradually with age. In Case 2, whose GMs in SI and TS mildy lessened, REMs were hardly noticed. Case 3 expressed only mild abnormalities of BMs.<BR>It is postulated that BMs reflect catecholaminergic activities of the brain and the serotonergic system plays an important role in producing and maintaining sleep. And it has also been reported in animals that congenital hypothyroidism can impair brain catecholaminergic and serotonergic systems. Our study suggests that hypothyroidism can also insult both systems in humans. It is important to evaluate the sleep development of patients with hypothyroidism and define the critical age of brain impairment.
収録刊行物
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- 脳と発達
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脳と発達 20 (4), 294-300, 1988
THE JAPANESE SOCIETY OF CHILD NEUROLOGY
