抗てんかん薬Carbamazepine (Tegretol) の血中濃度に関する研究 (予報)

DOI

書誌事項

タイトル別名
  • Preliminary Observations of Plasma Carbamazepine Concentration in Epileptic Children
  • 血中濃度/投与量の相関について
公開日
1976
DOI
  • 10.11251/ojjscn1969.8.455
公開者
THE JAPANESE SOCIETY OF CHILD NEUROLOGY

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説明

A preliminary study on the plasma concentration of carbamazepine (Tegretol) in children was performed as related with the oral dosage.<BR>Forty children at the pediatric seizure clinic of a university hospital (group A, aged 1-14, mean 8years) and 26 institutionalized both mentally and physically severely handicapped epileptic patients (group B, aged 5-23, mean 13 years) were selectedfor the study.<BR>Plasma levels of carbamazepine, phenobarbital, etc. were determined by the modification of Kupferberg's. GLC methods.<BR>In both groups A and B plasma carbamazepine Concentrations inμg/ml, plotted against dosage in mg/kg/day, showed great individual variation.<BR>However, there was a definite tendency that the patients taking carbamazepine, but not phenobarbital or primidone, showed high plasma level/dosage ratio ofcarbamazepine; while the carbamazepine plasma level, or plasma level/dosage ratio, was low in those on both carbamazepine and barbiturates, especially in those with high phenobarbital concentration above potentially toxic level.<BR>These probable drug interaction may have resulted in the differences of calculated values in both groups shown below.<BR>In group A, plasma levels (3.58±2.43μg/ml) to dosage (12.5±3.27mg/kg/day) ratios of carbamazepine were 0.28±0.18; and group B presented 1.83±1.38μg/ml, 13.10±7.19 mg/kg/day and 0.15±0.11, respectively.

収録刊行物

  • 脳と発達

    脳と発達 8 (6), 455-462, 1976

    THE JAPANESE SOCIETY OF CHILD NEUROLOGY

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