書誌事項
- タイトル別名
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- Neuroendocrinologic studies on autism.
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抄録
The cause of autism is unknown. Recently, it has been suggested that it involves metabolic disorders of serotonin and/or dopamine. On the other hand, there is a close relationship between hormone secretion and monoamines. The aim of this study was to analyze the secretion of GH, PRL, TSH, cortisol, LH and FSH.<BR>The subjects were 30 children with autism, 25 males and 5 females, aged from 1 10/12 to 9 10/12 years. Their IQs (DQs) ranged from 34 to 123. Pituitary hormone secretion was measured during provocation with insulin (0.1 unit/kg), TRH (10μg/kg) and/or LH-RH (100μg/m2) in 26 of 30 cases. Control subjects included 16 age-matched children with attention dificit disorder (ADD) and 18 age-matched children with mental retardation (MR) without autistic and organic central nervous diseases.The 24-hour secretion rhythm of GH, PRL and cortisol for 14 cases with autism and of LH and FSH for 9 cases was also investigated.<BR>In insulin provocation test, the peak values of GH and 4 GH (peak GH level minus baseline GH level) in ADD were significantly higher than those in MR (p<0.05). In TRH provocation test, the peak values of TSH and ΔTSH in autism were significantly lower than those in MR. Five cases of autistic children revealed borderline responses for TSH, while the only one each of ADDs and MRs revealed borderline responses for TSH. In a study of the 24-hour hormone secretion rhythm, eleven of the 14 autistic children showed an abnormal secretion rhythm.<BR>It was concluded that there are various types of neuroendocrinological abnormalities in autism, ADD and MR, and that the hypothalamic lesion in autism was different from that in MR or ADD.
収録刊行物
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- 脳と発達
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脳と発達 21 (2), 154-162, 1989
THE JAPANESE SOCIETY OF CHILD NEUROLOGY