Two Cases of Adult Down Syndrome Treated with Selective Serotonin Re-Uptake Inhibitor for Behavior Disorders

DOI PubMed 5 References
  • Hirayama Tsunenori
    Department of Pediatrics,. National Hospital Organization Fukushima Hospital
  • Kobayashi Tomoko
    Department of Pediatrics,. National Hospital Organization Fukushima Hospital
  • Fujita Takehisa
    Department of Pediatrics, Nippon Medical School Second Hospital
  • Fujino Osamu
    Department of Pediatrics, Nippon Medical School Chiba Hokuso Hospital

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Other Title
  • 成人Ｄｏｗｎ症候群２症例における自傷行為，興奮に対する選択的セロトニン再取り込み阻害剤（ＳＳＲＩ）の効果

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Adult patients with Down syndrome show psychological symptoms and early senility. Improving their environment and dealing with their complaints and stress should first address their behavioral problems, such as self-injury, depression, aggression and outbursts. Pharmacological treatment may also be tried for behavioral disorders. Individuals with Down syndrome demonstrate neurotransmitter changes such as the loss of acetylcholine, norepinephrine, and serotonin (5-HT) with increasing age. Selective serotonin re-uptake inhibitor (SSRI) is effective for depression and panic disorders.<BR>We report here the effect of SSRI in two adult male patients with Down syndrome, 35 and 47 years of age. Selfinjury in one case and aggression and outbursts in another improved after 1 week of fluvoxamine treatment, suggesting the effects of SSRI for behavioral disorders of adult Down syndrome.

Journal

  • NO TO HATATSU

    NO TO HATATSU 36 (5), 391-394, 2004

    THE JAPANESE SOCIETY OF CHILD NEUROLOGY

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