Adverse Effects of Dichloroacetate in a Girl with Mitochondrial Disorder.

DOI PubMed 13 References
  • Izumi Mina
    Department of Child Neurology, National Center Hospital for Mental, Nervous and Muscular Disorders, National Center of Neurology and Psychiatry
  • Hirayama Yasuhiro
    Department of Child Neurology, National Center Hospital for Mental, Nervous and Muscular Disorders, National Center of Neurology and Psychiatry
  • Sugai Kenji
    Department of Child Neurology, National Center Hospital for Mental, Nervous and Muscular Disorders, National Center of Neurology and Psychiatry
  • Fukumizu Michio
    Department of Child Neurology, National Center Hospital for Mental, Nervous and Muscular Disorders, National Center of Neurology and Psychiatry
  • Hanaoka Shigeru
    Department of Child Neurology, National Center Hospital for Mental, Nervous and Muscular Disorders, National Center of Neurology and Psychiatry
  • Sasaki Masayuki
    Department of Child Neurology, National Center Hospital for Mental, Nervous and Muscular Disorders, National Center of Neurology and Psychiatry
  • Kaga Makiko
    Department of Child Neurology, National Center Hospital for Mental, Nervous and Muscular Disorders, National Center of Neurology and Psychiatry
  • Murayama Keiko
    Department of Pediatrics, National Rehabilitation Center for Disabled Children

Bibliographic Information

Other Title
  • ジクロロ酢酸ナトリウム療法の投与量により活動性低下，肝腫大の副作用がみられたミトコンドリア病の１女児例

Search this article

Description

We present the effects and adverse effects of dichloroacetate (DCA) in a girl with mitochondrial disorder. Oral administration of DCA 50 mg/kg per day, reduced the elevated levels of lactate to below the normal range. Treatment with DCA ameliorated electroencephalogram abnormalities, but caused the adverse effects with hepatomegaly and decreased activity, which were improved by reduction or withdrawal of DCA. The decreased activity may bean adverse effect on the central nervous system. The dosage of DCA should be adjusted for each patient.

Journal

  • NO TO HATATSU

    NO TO HATATSU 35 (1), 54-58, 2003

    THE JAPANESE SOCIETY OF CHILD NEUROLOGY

References(13)*help

See more

Details 詳細情報について

Report a problem

Back to top