肺気相内ガス分布不均等のシミュレーション

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タイトル別名
  • Gas Transport in the Human Lung with Uneven Ventilation
  • ハイ キソウナイ ガス ブンプ フキントウ ノ シミュレーション

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説明

We have solved the gas transport equation for the model built from a modified form of Weibel's anatomical data to describe the airway geometry. The equation treats simultaneous convective flow and longitudinal diffusion and incorporates uneven distribution of ventilation.<BR>The slope of the alveolar plateau results in the main from regional inhomogeneity caused by the asynchronous ventilation in the airways. The stratified inhomogeneity is concurrently present as the secondary effects of regional inhomogeneity.<BR>The model was also used to explain the paradoxical phenomena of nitrogen washout tests in the patients with fibrosis, that is, the slope of the alveolar plateau of the single-breath washout test is steep in spite of the single exponential clearance curve of the multi-breath washout test on the same subject. The analysis of the solution of our equation leads us to the conclusion that : this phenomenon is caused by the following pulmonary characteristics of fibrosis : 1) the regional inhomogeneity throughout the distal airways, 2) the decrease of the regions in which diffusion plays a main role of gas transport, 3) the increased contribution of convective flow and 4) the increased relative common dead space to regional inhomogeneity.

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