Numerical Tests for Usefulness of Power-Law Formalism Method in Parameter Optimization Problem of Immobilized Enzyme Reaction.
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- Hasegawa Takahiro
- Department of Systems Engineering, Faculty of Engineering, Shizuoka University
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- Shiraishi Fumihide
- Department of Biochemical Engineering and Science, Kyushu Institute of Technology
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- Nagasue Hiroyuki
- Department of Chemical and Biological Engineering, Sasebo College of Technology
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Abstract
The performances of the power-law formalism method (PLFM) and Newton-Raphson method (NRM) are compared by applying them to a non-linear least square problem for determination of the maximum reaction rate, Vm, and Michaelis constant, Km, in an immobilized enzyme system following Michaelis-Menten kinetics. A detailed numerical investigation indicates that 1) the accuracies of the solutions (Vm and Km) obtained by these two methods are almost the same and very high; 2) however, the rate of convergence in PLFM is higher than that in NRM; and 3) the basin of attraction for PLFM is much wider than that of NRM. Advantages of PLFM are discussed based on the experimental data in the hydrolysis of soluble starch by glucoamylase immobilized on a porous honeycomb monolith. The result suggests that the nonlinear least-square method combined with PLFM is useful for many optimization problems in engineering fields.
Journal
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- JOURNAL OF CHEMICAL ENGINEERING OF JAPAN
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JOURNAL OF CHEMICAL ENGINEERING OF JAPAN 33 (2), 197-204, 2000
The Society of Chemical Engineers, Japan
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Keywords
Details 詳細情報について
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- CRID
- 1390282679541081472
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- NII Article ID
- 130000020398
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- NII Book ID
- AA00709658
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- COI
- 1:CAS:528:DC%2BD3cXislKht7w%3D
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- ISSN
- 18811299
- 00219592
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- NDL BIB ID
- 5352789
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed