AFM Observation of the Blocking of Step Motion Caused by L-Norleucine on (100) and (001) Faces of an L-Isoleucine Crystal

  • Kamei Toshimichi
    Fermentation and Biotechnology Laboratories, Isolation and Purification Technology Laboratory, Ajinomoto Co. Inc.
  • Hasegawa Kazuhiro
    Fermentation and Biotechnology Laboratories, Isolation and Purification Technology Laboratory, Ajinomoto Co. Inc.
  • Yokota Masaaki
    Department of Chemical Engineering, Iwate University
  • Doki Norihito
    Department of Chemical Engineering, Iwate University
  • Shimizu Kenji
    Department of Chemical Engineering, Iwate University

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The blocking of step motion on (100) and (001) faces of an L-isoleucine (L-Ile) crystal caused by the addition of an aqueous solution of L-norleucine (L-Nle) to the L-Ile solution was investigated using an atomic force microscope (AFM). The step motion was blocked in the presence of L-Nle. Crystal growth of L-Ile was inhibited along the a-, b-, and c-axes in the presence of L-Nle. Also, the blocking of step motion on the L-Ile (001) face of an L-Ile seed crystal was observed.

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