Pathology of parotid gland carcinomas

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  • 耳下腺癌の病理

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Abstract

Salivary gland neoplasms are relatively uncommon and nearly 80% of them occur in the parotid glands. The malignancies, most of which are carcininomas, make up about 20% of parotid gland tumors. Parotid gland carcinomas present a considerable diagnostic challenge for the general pathologists owing to their diverse histological features and the presence of a number of types and variants, in addition to overlapping histological patterns similar to those observed in different tumor entities. Furthermore, they are a heterogeneous group of tumors with different biologic behavior. The histological classification is complex, but is closely relevant to the prognostic and therapeutic aspects. Although hematoxylin-eosin staining is still the gold standard method used for the diagnosis, immunohistochemistry can enhance the accuracy and be a helpful tool when in cases to investigate the subjects that cannot be assessed by histological examination, such as the cell nature and differentiation status, cell proliferation rate, and oncogene protein expression. Recently, tumor specific recurrent chromosomal translocations resulting in the formation of fusion genes have been identified in mucoepidermoid carcinoma (CRTC1 [MECT1]-MAML2), adenoid cystic carcinoma (MYB-NFIB), and mammary analogue secretory carcinoma (ETV6-NTRK3). The fusion oncogenes may have diagnostic, prognostic, and future therapeutic implications.

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  • jibi to rinsho

    jibi to rinsho 59 (Suppl.1), S32-S37, 2013-12-20

    JIBI TO RINSHO KAI

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