Structure–Antiamnesic Activity Relationship of Iridoid Glycosides from Gardenia Fruits
-
- Kwak Jong Hwan
- School of Pharmacy, Sungkyunkwan University
-
- Lee Dong-Ung
- Division of Bioscience, Dongguk University
書誌事項
- 公開日
- 2015
- DOI
-
- 10.1246/cl.150172
- 公開者
- 公益社団法人 日本化学会
この論文をさがす
説明
We investigated the in vitro inhibitory acetylcholinesterase (AChE) activities and in vivo ameliorating effects on scopolamine-induced memory impairment of nine iridoid glycosides, namely, geniposide (1), genipin gentiobioside (2), gardenoside (3), scandoside methyl ester (4), deacetylasperulosidic acid methyl ester (5), 6-O-methyldeacetylasperulosidic acid methyl ester (6), geniposidic acid (7), gardoside (8), and shanzhiside (9), isolated from the fruits of Gardenia jasminoides (edible gardenia). Contrary to preliminary studies, genipin gentiobioside (2) exhibited the greatest anti-AChE activity (60.23 ± 2.12%) and antiamnesic effects (ca. 2-fold enhancement vs. the untreated control) using a passive avoidance task system, which is comparable to tacrine. Structure–activity relationships are suggested, which would be useful for identifying candidate compounds for the treatment of memory dysfunction.
収録刊行物
-
- Chemistry Letters
-
Chemistry Letters 44 (6), 837-839, 2015
公益社団法人 日本化学会
- Tweet
詳細情報 詳細情報について
-
- CRID
- 1390282679565567744
-
- NII論文ID
- 130005074585
-
- ISSN
- 13480715
- 03667022
-
- 本文言語コード
- en
-
- データソース種別
-
- JaLC
- Crossref
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可
