Biocompatibility and osteoconduction of bone defect fillers made from α-tricalcium phosphate and 50%-deacetylated chitosan based binders

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  • Kon Ryuichi
    Department of Dental Materials Science and Technology, Iwate Medical University School of Dentistry
  • Ichimaru Toshio
    Department of Dental Materials Science and Technology, Iwate Medical University School of Dentistry
  • Nagata Katsuhide
    Department of Dental Materials Science and Technology, Iwate Medical University School of Dentistry
  • Saito Setsuo
    Department of Dental Materials Science and Technology, Iwate Medical University School of Dentistry
  • Katsura Hirofumi
    Department of Dental Materials Science and Technology, Iwate Medical University School of Dentistry
  • Araki Yoshima
    Department of Dental Materials Science and Technology, Iwate Medical University School of Dentistry

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  • 50％ 脱アセチル化キチンを基剤とする賦形材と α型リン酸三カルシウムを複合した骨補填材の生体適合性および骨伝導能

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<p>New bone defect fillers (BDFs) were made from α-tricalcium phosphate and binders consisting of 50%-deacetylated chitosan with and without sodium alginate and diluted organic acid as solvent. Inflammatory response, bio-resorption and osteoconductivity were examined through studies with subcutaneous implantation of binders and bone implantation of BDFs. Histopathological images of host tissue were observed up to four weeks following implantation.The concentrations of acetic and citric acid at which chitosan dissolved exceeded 0.1 and 1.0 wt %, respectively. Adopting of chitosan thus made it possible to reduce acidity of the BDFs, which had not been possible in previous studies. Inflammatory response was higher for binder using chitosan alone than with chitosan and alginate, whereas it was scarcely different between kinds and concentrations of acid used. Bio-resorption was also higher for binder using chitosan alone than with chitosan and alginate. And it increased with acid concentration. Therefore, it was thought that inflammatory response and bio-resorption would appear possibly due to the water-soluble chitosan.In all bone implantations, the gap between the implanted bulk and bone cavity gradually was filled with newly-formed bone, thus diminishing the trabecular bone formation around the bulk. When citric acid was used, significantly higher conductivity was noted compared to acetic acid.Thus, it was suggested that adequate biocompatibility and osteoconductivity was clearly evident for all BDFs.</p><p></p>

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