バイオマーカーを用いた歯周病診断

DOI DOI Web Site Web Site Web Site ほか1件をすべて表示 一部だけ表示 参考文献48件
  • 木戸 淳一
    徳島大学大学院ヘルスバイオサイエンス研究部
  • 日野 真美
    （独）産業技術総合研究所健康工学研究センター
  • 板東 美香
    徳島大学大学院ヘルスバイオサイエンス研究部
  • 廣島 佑香
    徳島大学大学院ヘルスバイオサイエンス研究部

書誌事項

タイトル別名
  • Diagnosis of Periodontal Diseases by Biomarkers
  • バイオマーカー オ モチイタ シシュウビョウ シンダン

この論文をさがす

説明

Many middle aged and old persons take periodontal diseases that mainly cause teeth loss and result in some systemic diseases. The prevention of periodontal diseases is very important for oral and systemic health, but the present diagnostic examination is not fully objective and suitable. To diagnose periodontal diseases exactly, some biomarkers shown inflammation, tissue degradation and bone resorption, in gingival crevicular fluid (GCF) and saliva are known. We demonstrated that GCF levels of calprotectin, inflammation-related protein, and carboxy-terminal propeptide of type I procollagen, bone metabolism-related protein, were associated with clinical condition of periodontal diseases, and suggested that these proteins may be useful biomarkers for periodontal diseases. Recently, determinations of genes and proteins by using microdevices are studied for diagnosis of some diseases. We detected calprotectin protein by chemiluminescent immunoassay on a microchip and showed the possibility of specific and quantitative detection of calprotectin in a very small amount of GCF. To determine plural markers in GCF by using microdevices contributes to develop accurate, objective diagnostic system of periodontal diseases.

収録刊行物

参考文献 (48)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ