State-dependent Modulation of Cortical Synchrony by Vagus Nerve Stimulation in Adult Rats

DOI Web Site Web Site 6 References
  • Usami Kenichi
    Department of Neurosurgery, Graduate School of Medicine, The University of Tokyo
  • Kano Ryuji
    Department of Mechano-informatics, Graduate School of Information Science and Technology, The University of Tokyo
  • Kawai Kensuke
    Department of Neurosurgery, Graduate School of Medicine, The University of Tokyo
  • Noda Takahiro
    Research Center for Advanced Science and Technology, The University of Tokyo
  • Isoguchi Shiramatsu Tomoyo
    Department of Mechano-informatics, Graduate School of Information Science and Technology, The University of Tokyo
  • Saito Nobuhito
    Department of Neurosurgery, Graduate School of Medicine, The University of Tokyo
  • Takahashi Hirokazu
    Department of Mechano-informatics, Graduate School of Information Science and Technology, The University of Tokyo Research Center for Advanced Science and Technology, The University of Tokyo PRESTO, JST

Bibliographic Information

Other Title
  • 迷走神経刺激によるラット大脳皮質活動の同期度の状態依存的な調整
  • メイソウ シンケイ シゲキ ニ ヨル ラット ダイノウ ヒシツ カツドウ ノ ドウキド ノ ジョウタイ イソンテキ ナ チョウセイ

Search this article

Abstract

Vagus nerve stimulation (VNS) is a palliative treatment for intractable epilepsy. Therapeutic mechanisms of VNS have not been elucidated. In this study, we measured the local field potential (LFP) with high-spatial resolution using a microelectrode array in adult rats, and analyzed VNS-induced phase modulation at a local network level. Eight adult Wistar rats (270-330 g) were used. Each rat underwent implantation of VNS system under 1.5% isoflurane anesthesia. One week after implantation, right temporal craniotomy was performed under the same as previous anesthesia. Subsequently, a microelectrode array was placed in the temporal lobe cortex, and LFP was recorded with sampling rate of 1000 Hz. Phase-locking values (PLV) between all pairs of electrodes in varied frequency bands were calculated in order to evaluate the effect of VNS in terms of synchrony of neuronal activities. PLV was calculated both in a normal state and in an epileptic state induced by kainic acid. VNS increased PLV in a normal state, particularly in the high-γ band. In an epileptic state, on the other hand, VNS increased PLV in high-γ band, and decreased PLV in the δ and low-β bands. These results suggest that VNS modulates neural activities in a band-specific and state-dependent manner so as to keep cortical synchrony within the optimal state.

Journal

References(6)*help

See more

Related Projects

See more

Keywords

Details 詳細情報について

Report a problem

Back to top