Environmental Factors and Accumulation of Polycyclic Aromatic Hydrocarbons and Carbon in Human Lung.

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  • ヒト肺に蓄積した多環芳香族炭化水素および炭粉と環境要因について
  • ヒト ハイ ニ チクセキ シタ タカン ホウコウゾク タンカスイソ オヨビ タンフン ト カンキョウ ヨウイン ニ ツイテ

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Polycyclic aromatic hydrocarbons (PAHs) and Carbon which accumulated in human lung were measured, and the relations between concentration of pollutant and age, sex, smoking, residence region, occupation, or cause of death were examined. Thelung specimens (male 477, female 284) of the patients who had died at three hospitals, Tokyo in the period 1988-1993 were provided for the samples to analyze. The concentration levels of PAHs and carbon accumulated in male lungs were significantly higher than those of female lungs. The main accumulation factor of the pollutants in the lung was aging, and the second was occupation in the male group, and residence region or occupation in the female group. The contribution of smoking as the accumulation factor was low. The benzo [α] pyrene, benzo [g, h, i] perylene and carbon concentrations of lung cancer group among male were significantly higher than those of non-cancer group. The PAHs and carbonconcentrations in squamous cell carcinoma group among male were significantly higher than those in non-cancer group. Whereas, there was no difference of the concentration levels in the adenocarcinoma group with those in non-cancer group. Therefore, it was suggested that the difference of histological type of lung cancers is due to xenobiotica accumulation in lung tissue.<BR>On the basis of the results, there is a possibility that fine particulate matter (PM 2.5) associated with PAHs and carbon in atmosphere exerts the influence on an increase prevalenceoflung cancer.

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