Heparin-Selenocystamine Conjugate with Selenol Groups.

DOI Web Site Web Site PubMed 被引用文献3件 参考文献12件

書誌事項

タイトル別名
  • Heparin-Selenocystamine Conjugate with

この論文をさがす

説明

Heparin-selenocystamine conjugate, which was intended to mimic the heparin-selenoprotein P complex, was prepared. The conjugate had glutathione peroxidase-like activity and activity was observed toward hydrogen peroxide, tert-butyl hydroperoxide, and cumene hydroperoxide. The ultraviolet spectrum of an aqueous solution of the conjugate was stable and had a similar shape to that observed transiently when selenocystamine was reduced by sodium cyanoborohydride; this suggests that the diselenide bond of selenocystamine introduced into heparin was cleaved during conjugate preparation and the selenol group is preserved. The conjugated reacted to the same degree as cysteine with 5, 5'-dithiobis (2-nitrobenzoic acid) (DTNB) releasing thionitro-benzoic acid, which indicated that the selenium in the conjugate is present as selenol. However, the reaction rate of the conjugate was slower than cysteine which may be due to partially restricted access of DTNB to the selenol group in the conjugate. This conjugate had 1, 1-diphenyl-2-picryl-hydrazyl(DPPH) radical scavenging activity as well as superoxicde anion scavenging activity. These results indicate that the conjugate serves as a useful model compound with a stable selenol group having a range of biological activities, and suggest a possible antioxidant defensive role for the complex of endogenous heparin-like substance and selenoprotein P.

収録刊行物

被引用文献 (3)*注記

もっと見る

参考文献 (12)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ