Influence of OSW-1〔3β,16β,17α-Trihydroxycholest-5-en-22-one 16-O-(2-O-4-methoxybenzoyl-β-D-xylopyranosyl)-(1→3)-(2-O-acetyl-α-L-arabinopyranoside)〕,a Steroidal Saponin,on Endothelium Dependent Relaxation Caused by Acetylcholine in Rat Aorta

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  • Influence of OSW-1 (3.BETA.,16.BETA.,17.ALPHA.-Trihydroxycholest-5-en-22-one 16-O-(2-O-4-methoxybenzoyl-.BETA.-D-xylopyranosyl)-(1.RAR.3)-(2-O-acetyl-.ALPHA.-L-arabinopyranoside)), a Steroidal Saponin, on Endothelium Dependent Relaxation Caused by Acetylcholine in Rat Aorta.
  • Influence of OSW-1 3ベータ 16ベータ 17アルファ Tr

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The tension of isolated ring preparation of the aorta from rats was measured isometrically to study the influence of OSW-1 [3β, 16β, 17α-trihydroxycholest-5-en-22-one 16-O-(2-O-4-methoxybenzoyl-β-D-xylopyranosyl)-(1→3)-(2-O-acetyl-α-L-arabinopyranoside)], a steroidal saponin, on the endothelium dependent and independent relaxation caused by acetylcholin (ACh) and sodium nitroprusside (SNP), respectively. OSW-1 (10-7 M), which has more than 100 times higher concentration for anti-tumor activity, had no influence on either the endothelium dependent or independent relaxation. OSW-1 (10-6M, 0.9 μg/ml) slightly reduced the endothelium dependent relaxation caused by ACh but did not affect the SNP-induced relaxation. In contrast to OSW-1, 1 mg/ml of saponin significantly suppressed the ACh-induced relaxation and shifted the dose-relaxation curve for SNP to the right. OSW-1 (10-7 and 10-6 M) did not affect the norepinephrine-induced contraction but 1 mg/ml of saponin significantly attenuated it. The results suggest that though the higher concentration of OSW-1 shows weaker influence on the endothelium function compared with saponin, OSW-1 at an anti-tumor dose has no influence on either endothelium or smooth muscle function.

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