Cyclodextrin-induced hemolysis and shape changes of human erythrocytes in vitro.
書誌事項
- 公開日
- 1982
- 資源種別
- journal article
- DOI
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- 10.1248/bpb1978.5.741
- 公開者
- 公益社団法人 日本薬学会
この論文をさがす
説明
Cyclodextrins (CyDs) at higher concentrations were found to cause hemolysis of human erythrocytes in the order of β->α->γ-CyD in isotonic solution. Biphasic effects of CyDs were observed for the osmotic and heat-induced hemolysis; i.e. the protection at relatively low CyD concentrations and stimulation at higher CyD concentrations. From the scanning electron microscopic observations, CyDs induced shape changes of membrane internalization type on erythrocytes. CyDs caused the release of cholesterol from erychrocyte membrane in the order of β->γ->α-CyD. These results dearly indicate that CyD-induced hemolysis is probably a secondary event resulting from the membrane disruption which elicited the removal of membrane components from erythrocytes.
収録刊行物
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- Journal of Pharmacobio-Dynamics
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Journal of Pharmacobio-Dynamics 5 (9), 741-744, 1982
公益社団法人 日本薬学会
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キーワード
詳細情報 詳細情報について
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- CRID
- 1390282679599014016
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- NII論文ID
- 130003544596
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- COI
- 1:CAS:528:DyaL38XmtVyjtrs%3D
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- ISSN
- 18811353
- 0386846X
- http://id.crossref.org/issn/0386846X
- https://id.crossref.org/issn/0386846X
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- PubMed
- 7153847
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- 本文言語コード
- en
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- 資料種別
- journal article
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- データソース種別
-
- JaLC
- Crossref
- PubMed
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可
