The Bmect of Feeding Carrots on Immunoglobulin E Production and Anaphylactic Response in Mice

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  • The Effect of Feeding Carrots on Immunoglobulin E Production and Anaphylactic Response in Mice.
  • Bmect of Feeding Carrots on Immunoglobulin E Production and Anaphylactic Response in Mice

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Carrot juice was administered orally to BALB/c mice immunized intraperitoneally with dinitrophenylated(DNP)-OVA for about 1 month. The titers of DNP-specific IgE, DNP-specific IgG, and the levels of total IgE in mouse sera were determined. The DNP-specific IgE production by mice fed carrot juice was significantly ingibited. On the other hand, the DNP-specific IgG production and the level of total IgE in mice fed carrot juice were not significantly different from those in control mice. We also examined the effect of feeding carrots on immediate-type htpersensitivity. One hour after antigen stimulation, the ears of mice fed carrots swelled less than those of control mice. Furthermore, the rise in serum histamine in the mice fed carrots under active systemic anaphylaxis was lower than in controls.We then examined the pattern of cytokine production by spleen cells from mice followed by restimulation with DNP-OVA in vitro. The spleen cells from the mice fed carrots produced more interferon-γ than those form the control group. In contrast, the spleen cells from the mice fed carrots produced less interleukin-4 than those form the control group. Furthermore, the interleukin-12 production of the spleen cells from mice fed carrots was aslo higher than that of the control group. These findings suggest that feeding carrots improves the helper T cell(Th)1/Th2 balance, inhibiting specific IgE production and antigen-induced anaphylactic response.

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