Four Di-O-caffeoyl Quinic Acid Derivatives from Propolis. Potent Hepatoprotective Activity in Experimental Liver Injury Models.
書誌事項
- タイトル別名
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- Four Di-O-caffeoyl Quinic Acid Derivati
- 公開日
- 1996
- 資源種別
- journal article
- DOI
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- 10.1248/bpb.19.1479
- 公開者
- 公益社団法人 日本薬学会
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説明
The water extract of propolis (PWE) showed a strong hepatoprotective activity against CCl4-toxicity in rats and D-galactosamine (GalN)/lipopolysaccharide (LPS)-induced liver injury in mice. The PWE also showed a significant hepatoprotective activity against CCl4-induced liver cell injury in cultured rat hepatocytes. The in vitro hepatoprotective activity guided fractionation and chemical analysis led to the isolation of four dicaffeoyl quinic acid derivatives from the PWE. The structure of these isolated was determined to be methyl 3, 4-di-O-caffeoyl quinate (1), 3, 4-di-O-caffeoyl quinic acid (2), methyl 4, 5-di-O-caffeoyl quinate (3), and 3, 5-di-O-caffeoyl quinic acid (4) by spectroscopic method. These compounds were more potent hepatoprotective agents than glycyrrhizin at a concentration of 10 μg/ml and 1 was the most potent among the four compounds in the cultured hepatocytes. Quinic acid (5) alone did not show hepatoprotective effects in cultured rat hepatocytes against CCl4-toxicity. On the other hand, chlorogenic acid (6) or caffeic acid alone was found to be less potent than the dicaffeoyl quinic acid derivatives.
収録刊行物
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- Ｂｉｏｌｏｇｉｃａｌ ＆ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｂｕｌｌｅｔｉｎ
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Ｂｉｏｌｏｇｉｃａｌ ＆ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｂｕｌｌｅｔｉｎ 19 (11), 1479-1484, 1996
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390282679600024192
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- NII論文ID
- 110003663351
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- NII書誌ID
- AA10885497
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- COI
- 1:CAS:528:DyaK28Xnt1Oqu7w%3D
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- ISSN
- 13475215
- 09186158
- https://id.crossref.org/issn/09186158
- http://id.crossref.org/issn/09186158
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- NDL書誌ID
- 4080092
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- PubMed
- 8951168
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- 本文言語コード
- en
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- 資料種別
- journal article
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- データソース種別
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- JaLC
- NDLサーチ
- Crossref
- PubMed
- CiNii Articles
- OpenAIRE
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- 抄録ライセンスフラグ
- 使用不可