- 【Updated on May 12, 2025】 Integration of CiNii Dissertations and CiNii Books into CiNii Research
- Trial version of CiNii Research Knowledge Graph Search feature is available on CiNii Labs
- Suspension and deletion of data provided by Nikkei BP
- Regarding the recording of “Research Data” and “Evidence Data”
Enhancing Effect of 2-O-.ALPHA.-D-Glucopyranosyl-L-ascorbic Acid, a Stable Ascorbic Acid Derivative, on Collagen Synthesis.
Bibliographic Information
- Other Title
-
- Enhancing Effect of 2-O-α-D-Glucopyranosyl-L-ascorbic Acid,a Stable Ascorbic Acid Derivative,on Collagen Synthesis
- Enhancing Effect of 2 O アルファーD Glucopyr
Search this article
Description
The objective of the present study was to compare 2-O-α-D-gludopyranosyl-L-ascorbic acid (AA-2G) with ascorbic acid (AA) and ascorbic acid 2-phosphate (AA-2P) concerning the promotion of collagen production in human skin fibroblasts.Though AA-2G was still observed to be promoting collagen synthesis at the same level on the 8th day of the culture, collagen synthesis was seen to decrease on the fifth day of culturing with AA and AA-2P. This sustained collagen synthesis-promoting action is considered to be a major feature of the novel vitamin C derivative, AA-2G by conducting an experiment in which an α-glucosidase inhibitor was present, it was shown that AA-2G exerts its collagen synthesis-promoting action after being decomposed to AA by α-glucosidase. Further, we observed that for AA-2G, even on the 8th day of the culture, the amount of AA in the fibroblasts was virtually unchanged from the beginning of the experiment, whereas, in the case of adding AA and AA-2P, virtually no AA was detectable in the culture medium on the fifth day.These findings suggests that AA-2G in decomposed to AA by α-glucosidase in the cells. This AA promotes collagen synthesis, which is prolonged through AA-2G's sustained decomposition.
Journal
-
- Biological and Pharmaceutical Bulletin
-
Biological and Pharmaceutical Bulletin 21 (7), 662-666, 1998
The Pharmaceutical Society of Japan
- Tweet
Details 詳細情報について
-
- CRID
- 1390282679600025600
-
- NII Article ID
- 110003639436
-
- NII Book ID
- AA10885497
-
- COI
- 1:CAS:528:DyaK1cXkslyjur8%3D
-
- ISSN
- 13475215
- 09186158
- http://id.crossref.org/issn/09186158
-
- NDL BIB ID
- 4538473
-
- PubMed
- 9703245
-
- Text Lang
- en
-
- Article Type
- journal article
-
- Data Source
-
- JaLC
- NDL Search
- Crossref
- PubMed
- CiNii Articles
- OpenAIRE
-
- Abstract License Flag
- Disallowed