Change of β-Endorphin Concentration in Rat Brain after Administration of Indomethacin or Carrageenin
書誌事項
- タイトル別名
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- Change of .BETA.-Endorphin Concentration in Rat Brain after Administration of Indomethacin or Carrageenin.
- Change of ベーターEndorphin Concentration i
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This study aimed to investigate the behavior of an endogenous β-endorphin (β-EP) in the brain after subcutaneous (s.c.) injection of carrageenin or intravenous (i.v.) injection of indomethacin (IDM). The carrageenin was injected into rat hind paw subcutaneously in order to evoke only a local nociceptive stimulus. The β-EP concentration in the brain region was determined by radioimmunoassay at designated sampling times after the injection. It was observed that the β-EP concentration in the midbrain declined from 2.8±0.3 at 1 h to 1.3±0.02 ng/mg protein at 9h. After the s.c. injecction of carrageenin, the β-EP concentrations in the midbrain were found to be closely related to the nociceptive sensitivity which was determined by the Randall-Selitto test. On the other hand, a significant elevation of the β-EP concentration was observed in the hypothalamus from 3 h until 5 h compared with that of control. IDM was injected into rats at doses of 2.9, 5.8 and 8.6 mg/kg via the femoral vein. After i.v. administration of IDM, the β-EP increased in the hypothalamus, medulla oblongata, and midbrain, depending on the doses used. The value of hypothalamic β-EP concentration was two times higher than that of carrageenin. We found that nociceptive stimuli and IDM brought a change in the β-EP concentration in the brain of rats.
収録刊行物
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- Biological & Pharmaceutical Bulletin
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Biological & Pharmaceutical Bulletin 21 (7), 756-760, 1998
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390282679600259456
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- NII論文ID
- 110003639454
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- NII書誌ID
- AA10885497
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- ISSN
- 13475215
- 09186158
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- NDL書誌ID
- 4538492
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- PubMed
- 9703263
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
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- 抄録ライセンスフラグ
- 使用不可