Study on the Relationship of APACHE III and Levels of Cytokines in Patients with Systemic Inflammatory Response Syndrome after Coronary Artery Bypass Grafting

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  • Mei Yun Qing
    Heart-Lung-Blood Vessel Center of Tongji University, Institute of Heart-Lung-Blood Vessel Disease of Tongji University, Department of Thoracic Cardiovascular Surgery of Tongji Hospital of Tongji University
  • Ji Qiang
    Heart-Lung-Blood Vessel Center of Tongji University, Institute of Heart-Lung-Blood Vessel Disease of Tongji University, Department of Thoracic Cardiovascular Surgery of Tongji Hospital of Tongji University
  • Liu Hua
    Division of Heart Surgery, Zhongshan Hospital, Fudan University
  • Wang Xisheng
    Heart-Lung-Blood Vessel Center of Tongji University, Institute of Heart-Lung-Blood Vessel Disease of Tongji University, Department of Thoracic Cardiovascular Surgery of Tongji Hospital of Tongji University
  • Feng Jing
    Heart-Lung-Blood Vessel Center of Tongji University, Institute of Heart-Lung-Blood Vessel Disease of Tongji University, Department of Thoracic Cardiovascular Surgery of Tongji Hospital of Tongji University
  • Long Cun
    CPB Dept. of Fuwai Hospital, P.R.China
  • Cheng Bangchang
    Dept. of Thoraco-Cardiovascular Surgery of People's Hospital, Wuhan University
  • Xing Yan
    Heart-Lung-Blood Vessel Center of Tongji University
  • Li Jue
    Heart-Lung-Blood Vessel Center of Tongji University, Institute of Heart-Lung-Blood Vessel Disease of Tongji University, Division of Epidemiology of Tongji University
  • Hu Dayi
    Heart-Lung-Blood Vessel Center of Tongji University

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Other Title
  • Study on the Relationship of APACHE 3 and Levels of Cytokines in Patients with Systemic Inflammatory Response Syndrome after Coronary Artery Bypass Grafting

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Abstract

The aim of this study was to explore the relationship and interpret the clinical importance of acute physiology and chronic health evaluation III (APACHE III) and levels of cytokines in patients with systemic inflammatory response syndrome (SIRS) after coronary artery bypass grafting (CABG) with or without cardio-pulmonary bypass (CPB) to see if they are beneficial for evaluating the seriousness of SIRS. The data suggested that the APACHE III score and levels of interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), interleukin-1 beta (IL-1β), and soluble interleukin-2 receptor (sIL-2R) were significantly higher after conventional CABG (CCABG) than after off-pump coronary artery bypass grafting (OPCAB) (p<0.05). With an increase in the APACHE III score, the levels of IL6, IL8, TNF-α, IL-1β, and sIL-2R and the morbidity of multiple organ dysfunction syndrome (MODS) increased gradually (p<0.01), while the level of IL2 decreased (p<0.01). Stepwise regression analysis showed that IL-1β, IL6, IL8, and sIL-2R levels had significant influences on the APACHE III score (p<0.05). The APACHE III score and levels of IL6, IL8, TNF-α, IL-1β, and sIL-2R were significantly higher in the MODS group than in the non-MODS group (p<0.05), but the level of IL2 was significantly lower in the MODS group (p=0.04). In conclusion, despite comparable surgical trauma, we believe that CPB is one of the most important factors responsible for stimulating an inflammatory response. SIRS after OPCAB was clearly mitigated compared with CCABG. Determination of the APACHE III score and plasma IL-1β, IL6, IL8 and sIL-2R concentrations might be helpful for evaluating the severity of SIRS following CABG and making a prognosis.

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