Antioxidant Activity of Jionoside D from Clerodendron trichotomum

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  • Chae Sungwook
    Natural Products Research Institute and College of Pharmacy, Seoul National University
  • Kim Ju Sun
    Natural Products Research Institute and College of Pharmacy, Seoul National University
  • Kang Kyoung Ah
    Department of Biochemistry and Applied Radiological Science Research Institute, College of Medicine, Cheju National University
  • Bu Hyung Deuk
    Department of Biochemistry and Applied Radiological Science Research Institute, College of Medicine, Cheju National University
  • Lee Youngki
    Department of Histology, College of Medicine, Cheju National University
  • Hyun Jin Won
    Department of Biochemistry and Applied Radiological Science Research Institute, College of Medicine, Cheju National University
  • Kang Sam Sik
    Natural Products Research Institute and College of Pharmacy, Seoul National University

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The antioxidant property of jionoside D, isolated from Clerodendron trichotomum (Verbenaceae), was investigated. This compound showed scavenging activity of intracellular reactive oxygen species and of 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical, as well as lipid peroxidation inhibitory activity. This radical scavenging activity of jionoside D protected the cell viability of Chinese hamster lung fibroblast (V79-4) cells exposed H2O2. Furthermore, jionoside D reduced the apoptotic cells induced by H2O2, as demonstrated by the decreased number of sub G1 hypo-diploid cells and apoptotic body formation. However, it increased the activities of cellular antioxidant enzymes, superoxide dismutase and catalase. Taken together, these findings suggest that jionoside D, isolated from C. trichotomum, exhibits antioxidant properties.

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