Melanin Biosynthesis Inhibitors from the Bark of Machilus thunbergii
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- Li Gao
- College of Pharmacy, Yeungnam University
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- Ju Hye Kyung
- College of Pharmacy, Yeungnam University
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- Chang Hyuen Wook
- College of Pharmacy, Yeungnam University
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- Jahng Yurngdong
- College of Pharmacy, Yeungnam University
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- Lee Seung-Ho
- College of Pharmacy, Yeungnam University
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- Son Jong-Keun
- College of Pharmacy, Yeungnam University
書誌事項
- 公開日
- 2003
- 資源種別
- journal article
- DOI
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- 10.1248/bpb.26.1039
- 公開者
- 公益社団法人 日本薬学会
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説明
The bioassay-guided fractionation of the methylene chloride soluble portion of a methanol extract of Machilus thunbergii bark led to the isolation of four known lignans, machilin A (1), meso-monomethyl dihydroguaiaretic acid (2), nectandrin A (3) and nectandrin B (4), which exhibited potent inhibitory activity on melanin biosynthesis in cultured B-16 mouse melanoma cells (IC50: 39.9, 15.1, 19.4 and 37.8 μM, respectively).
収録刊行物
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- Ｂｉｏｌｏｇｉｃａｌ ＆ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｂｕｌｌｅｔｉｎ
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Ｂｉｏｌｏｇｉｃａｌ ＆ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｂｕｌｌｅｔｉｎ 26 (7), 1039-1041, 2003
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390282679601594624
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- NII論文ID
- 110003608572
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- NII書誌ID
- AA10885497
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- COI
- 1:CAS:528:DC%2BD3sXmsFWnt78%3D
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- ISSN
- 13475215
- 09186158
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- NDL書誌ID
- 6583746
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- PubMed
- 12843636
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- 本文言語コード
- en
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- 資料種別
- journal article
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- データソース種別
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- JaLC
- NDLサーチ
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可