Melanin Biosynthesis Inhibitors from the Bark of Machilus thunbergii

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Bibliographic Information

Published
2003
Resource Type
journal article
DOI
  • 10.1248/bpb.26.1039
Publisher
The Pharmaceutical Society of Japan

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Description

The bioassay-guided fractionation of the methylene chloride soluble portion of a methanol extract of Machilus thunbergii bark led to the isolation of four known lignans, machilin A (1), meso-monomethyl dihydroguaiaretic acid (2), nectandrin A (3) and nectandrin B (4), which exhibited potent inhibitory activity on melanin biosynthesis in cultured B-16 mouse melanoma cells (IC50: 39.9, 15.1, 19.4 and 37.8 μM, respectively).

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