Antidiabetic Activity of Lyophyllum decastes in Genetically Type 2 Diabetic Mice.

DOI Web Site Web Site PubMed 被引用文献9件 参考文献35件
  • Miura Toshihiro
    Department of Clinical Nutrition, Suzuka University of Medical Science
  • Kubo Mizue
    Department of Clinical Nutrition, Suzuka University of Medical Science
  • Itoh Yasushi
    Department of Clinical Nutrition, Suzuka University of Medical Science
  • Iwamoto Naoki
    Department of Clinical Nutrition, Suzuka University of Medical Science
  • Kato Motoshi
    Department of Clinical Nutrition, Suzuka University of Medical Science
  • Park Sang Rae
    Graduate School of Medical Imaging, Suzuka University of Medical Science
  • Ukawa Yuuichi
    Research Center Eishogen Co., Ltd.
  • Kita Yukio
    Research Center Eishogen Co., Ltd.
  • Suzuki Ikukatsu
    Department of Clinical Nutrition, Suzuka University of Medical Science

この論文をさがす

抄録

The antidiabetic activity of Lyophyllum decastes (Tricholomataceae) was investigated in KK-Ay mice, an animal model of genetically type 2 diabetes with hyperinsulinemia. The water extract of Lyophyllum decastes (LD) (500 mg/kg body weight) reduced the blood glucose of KK-Ay mice 7 h after a single oral administration (p<0.05) when compared with control. LD reduced the blood glucose of KK-Ay mice 3 weeks after repeated administration (p<0.05), and also significantly lowered the serum insulin of KK-Ay mice under similar conditions (p<0.01). However, LD did not affect the blood glucose in normal mice. LD tended to decrease of the blood glucose in an insulin tolerance test. In addition, the muscle content of facilitative glucose transporter isoform 4 (GLUT4) protein content in the plasma membrane fraction from muscle significantly increased in the orally LD-treated KK-Ay mice when compared to that of the controls (p<0.01). These results suggest that the antidiabetic activity of LD is derived, at least in part, from a decrease in insulin resistance, due to the increase of GLUT4 protein content in the plasma membrane of the muscle.

収録刊行物

被引用文献 (9)*注記

もっと見る

参考文献 (35)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ