Metabolism of 6″-O-Xylosyltectoridin and Tectoridin by Human Intestinal Bacteria and Their Hypoglycemic and in Vitro Cytotoxic Activities
書誌事項
- タイトル別名
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- Metabolism of 6''-O-Xylosyltectoridin and Tectoridin by Human Intestinal Bacteria and Their Hypoglycemic and in Vitro Cytotoxic Activities.
- 公開日
- 1999
- 資源種別
- journal article
- DOI
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- 10.1248/bpb.22.1314
- 公開者
- 公益社団法人 日本薬学会
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説明
6"-O-Xylosyltectoridin and tectoridin isolated from the flowers of Pueraria thunbergiana (Leguminosae), are metabolized to tectorigenin by human intestinal bacteria. Although tectoridin is metabolized to tectorigenin by most intestinal bacteria, 6"-O-xylosyltectoridin is metabolized to tectorigenin via tectoridin by only a few intestinal bacteria, such as Bifidobacterium breve K-110 and Eubacterium A-44. The metabolite, tectorigenin, had more potent hypoglycemic activity as well as in vitro cytotoxic activity against tumor cell lines than 6"-O-xylosyltectoridin and tectoridin. These results suggest that 6"-O-xylosyltectoridin and tectoridin. These results suggest that 6"-O-xylosyltectoridin and tectoridin are prodrugs which can be transformed to the active agents by human intestinal bacteria.
収録刊行物
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- Ｂｉｏｌｏｇｉｃａｌ ＆ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｂｕｌｌｅｔｉｎ
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Ｂｉｏｌｏｇｉｃａｌ ＆ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｂｕｌｌｅｔｉｎ 22 (12), 1314-1318, 1999
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390282679601688192
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- NII論文ID
- 110003639602
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- NII書誌ID
- AA10885497
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- COI
- 1:CAS:528:DC%2BD3cXitlWi
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- ISSN
- 13475215
- 09186158
- https://id.crossref.org/issn/09186158
- http://id.crossref.org/issn/09186158
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- NDL書誌ID
- 4938493
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- PubMed
- 10746163
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- 本文言語コード
- en
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- 資料種別
- journal article
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- データソース種別
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- JaLC
- NDLサーチ
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可