The Immunological Effects of Electrolyzed Reduced Water on the Echinostoma hortense Infection in C57BL/6 Mice

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  • Lee Kyu Jae
    Department of Environmental Medical Biology, Wonju College of Medicine, Yonsei University Institute of Lifelong Health, Wonju College of Medicine, Yonsei University
  • Jin Dan
    Department of Immunology and Pathogenic Biology, College of Basic Medicine, Yanbian University
  • Chang Byung Soo
    Department of Cosmetology, Hanseo University
  • Teng Yung Chien
    Department of Environmental Medical Biology, Wonju College of Medicine, Yonsei University Institute of Basic Medical Science, Wonju College of Medicine, Yonsei University
  • Kim Dong Heui
    Department of Environmental Medical Biology, Wonju College of Medicine, Yonsei University Institute of Basic Medical Science, Wonju College of Medicine, Yonsei University

書誌事項

公開日
2009
DOI
  • 10.1248/bpb.32.456
公開者
公益社団法人 日本薬学会

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説明

Electrolyzed reduced water (ERW) is widely used for drinking by people in Asia. The purpose of this study was to examine the immunological effect of ERW on the immunity of animals by supplying ERW to C57BL/6 mice infected with Echinostoma hortense metacercariae. In the non-infected groups, interleukin (IL)-4 (p<0.001), IL-5, IL-10, IL-1β, tumor necrosis factor (TNF)-α and immunoglobulin (Ig) A expression of the group fed ERW (ERW group) increased in small intestine compared with the normal control group. In the case of infected groups, the group fed ERW (ERW+E. hortense group) showed the result that IL-4, IL-5, IL-10 and Ig A expression increased, but IL-1β and TNF-α (p<0.001) decreased, and the number of goblet cells (p<0.001) and helix pomatia agglutinin (HPA) positive cells increased compared with the group without feeding ERW. However, adult worm recovery rate was markedly increased (p<0.05). On the other hand, the expression of all the cytokines except IL-10 in spleen was mildly increased but not significant statistically, and there was no significant difference in the numerical changes of white blood cell (WBC). These results indicate that feeding ERW may have influence on the local immune response (Th-1 type cytokines such as IL-1β, TNF-α) in the small intestine but not on the systemic immune response.

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