N-trans-Feruloyltyramine as a Melanin Biosynthesis Inhibitor
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- Efdi Mai
- Department of Chemistry, Faculty of Engineering, Gifu University
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- Ohguchi Kenji
- Gifu International Institute of Biotechnology
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- Akao Yukihiro
- Gifu International Institute of Biotechnology
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- Nozawa Yoshinori
- Gifu International Institute of Biotechnology
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- Koketsu Mamoru
- Division of Instrumental Analysis, Life Science Research Center, Gifu University
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- Ishihara Hideharu
- Department of Chemistry, Faculty of Engineering, Gifu University
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Abstract
In this study, we examined the effect of N-trans-feruloyltyramine (FA) on melanogenesis in mouse B16 melanoma cells. Melanogenesis was inhibited by FA in a dose-dependent manner. FA exhibited a greater potency than kojic acid as a standard inhibitor of melanogenesis. Moreover, treatment of B16 melanoma cells with FA was found to cause marked decreases in the expression levels of tyrosinase. FA-induced downregulation of tyrosinase resulted in suppression of melanin biosynthesis in murine B16 melanoma cells.
Journal
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- Biological and Pharmaceutical Bulletin
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Biological and Pharmaceutical Bulletin 30 (10), 1972-1974, 2007
The Pharmaceutical Society of Japan
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Keywords
Details 詳細情報について
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- CRID
- 1390282679601839104
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- NII Article ID
- 110006436388
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- NII Book ID
- AA10885497
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- ISSN
- 13475215
- 09186158
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- HANDLE
- 20.500.12099/31908
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- NDL BIB ID
- 8919665
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- Text Lang
- en
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- Data Source
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- JaLC
- IRDB
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed