N-trans-Feruloyltyramine as a Melanin Biosynthesis Inhibitor

Efdi Mai, Ohguchi Kenji, Akao Yukihiro, Nozawa Yoshinori, Koketsu Mamoru, Ishihara Hideharu

doi:10.1248/bpb.30.1972

N-trans-Feruloyltyramine as a Melanin Biosynthesis Inhibitor

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Efdi Mai

Department of Chemistry, Faculty of Engineering, Gifu University
Ohguchi Kenji

Gifu International Institute of Biotechnology
Akao Yukihiro

Gifu International Institute of Biotechnology
Nozawa Yoshinori

Gifu International Institute of Biotechnology
Koketsu Mamoru

Division of Instrumental Analysis, Life Science Research Center, Gifu University
Ishihara Hideharu

Department of Chemistry, Faculty of Engineering, Gifu University

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In this study, we examined the effect of N-trans-feruloyltyramine (FA) on melanogenesis in mouse B16 melanoma cells. Melanogenesis was inhibited by FA in a dose-dependent manner. FA exhibited a greater potency than kojic acid as a standard inhibitor of melanogenesis. Moreover, treatment of B16 melanoma cells with FA was found to cause marked decreases in the expression levels of tyrosinase. FA-induced downregulation of tyrosinase resulted in suppression of melanin biosynthesis in murine B16 melanoma cells.