Constrictor Responses to Noradrenaline, Hemodynamic Profile, and Superoxide Levels Measured by Hydroethidine Oxidation in Diabetic Rats
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- Sartoretto Juliano Luiz
- Department of Pharmacology, Institute of Biomedical Sciences, University of São Paulo
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- Oliveira Maria Aparecida
- Department of Pharmacology, Institute of Biomedical Sciences, University of São Paulo
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- Nigro Dorothy
- Department of Pharmacology, Institute of Biomedical Sciences, University of São Paulo
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- Carvalho Maria Helena Catelli
- Department of Pharmacology, Institute of Biomedical Sciences, University of São Paulo
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- Tostes Rita Cassia
- Department of Pharmacology, Institute of Biomedical Sciences, University of São Paulo
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- Fortes Zuleica Bruno
- Department of Pharmacology, Institute of Biomedical Sciences, University of São Paulo
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The aim of this study was to test the hypothesis that vascular dysfunction in neonatal streptozotocin (n-STZ)-induced diabetic rats could be associated with alterations in blood pressure, hemodynamic profile, and levels of superoxide anion. Diabetes was induced by STZ injection (160 mg/kg, i.p.) in neonate (2-d-old) Wistar rats. Using intravital microscopy the changes in mesenteric arteriolar diameters to vasoconstrictor agent noradrenaline (NA) and the levels of superoxide anion, measured by hydroethidine microfluorography, were determined in anaesthetized control and n-STZ rats. Blood pressure (BP) was determined in anaesthetized and unanaesthetized animals. Heart rate, shear rate, and blood flow velocity were also assessed. n-STZ rats showed, after 8 weeks of STZ injection, increased BP (unanaesthetized animals), hyperactivity to NA, and increased superoxide anion levels. However, heart rate, arteriolar shear rate, and blood flow velocity were unchanged in n-STZ. In conclusion, the results of the current study describe a significant increase in blood pressure, hyperactivity to NA-mediated vasoconstriction, and increased superoxide levels measured by hydroethidine oxidation. Taken together, our findings demonstrate that the compromised ability of mesenteric microvessels to respond properly in n-STZ diabetic rats is associated with several vascular alterations.
収録刊行物
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- Biological & Pharmaceutical Bulletin
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Biological & Pharmaceutical Bulletin 30 (10), 1938-1942, 2007
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390282679601856512
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- NII論文ID
- 110006436379
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- NII書誌ID
- AA10885497
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- ISSN
- 13475215
- 09186158
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- NDL書誌ID
- 8919352
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
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