Preventive Effect of Water Containing Magnesium Ion on Paw Edema in Adjuvant-Induced Arthritis Rat
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- Nagai Noriaki
- Kinki University School of Pharmacy
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- Fukuhata Takashi
- Kinki University School of Pharmacy
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- Ito Yoshimasa
- Kinki University School of Pharmacy Department of Protein Biochemistry, Tokyo Metropolitan Institute of Gerontology
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- Tai Hideyuki
- Technical Development Department, AKO KASEI Co., Ltd.
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- Hataguchi Yoshihiro
- Technical Development Department, AKO KASEI Co., Ltd.
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- Nakagawa Koji
- Technical Development Department, AKO KASEI Co., Ltd.
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Abstract
We demonstrate the preventive effect of bittern water (BW), which enables the effective intake of magnesium ion (Mg2+), on paw edema in adjuvant-induced arthritis (AA) rat. BW (five kinds; BW-1, 2, 3, 4, 5) containing 10—200 mg/l Mg2+ was used in this study. Arthritis was induced by the injection of 50 μl of a suspension of 10 mg/ml heat-killed butyricum (Mycobacterium butyricum) in Bayol F oil into the plantar region of the right hind foot and tail of rats. Paw edema of the right and left hind feet of AA rats were reduced by the administration of BW for 14 d after adjuvant injection in comparison with those of AA rats administered purified water. The preventive effect increased with the increasing Mg2+ content of the BW. In addition, a combination of indomethacin (IM, 2 mg/kg) and BW-5 (200 mg/l Mg2+) prevented paw edema of the right and left hind feet of AA rats in comparison with IM alone. The fate of plasma IM after the oral administration of the combined IM (2 mg/kg/d) and BW-5 was similar to that after the administration of IM alone. In conclusion, the oral administration of Mg2+ to AA rats potently prevents the development of inflammation, and the combination of IM and Mg2+ may provide an effective therapy of arthritic edema.
Journal
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- Biological and Pharmaceutical Bulletin
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Biological and Pharmaceutical Bulletin 30 (10), 1934-1937, 2007
The Pharmaceutical Society of Japan
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Details 詳細情報について
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- CRID
- 1390282679601857920
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- NII Article ID
- 110006436378
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- NII Book ID
- AA10885497
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- ISSN
- 13475215
- 09186158
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- NDL BIB ID
- 8919338
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed