No Association of the G1287A Polymorphism in the Norepinephrine Transporter Gene and Susceptibility to Major Depressive Disorder in a Japanese Population
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- Inoue Kazuyuki
- Department of Pharmaceutical Science, Akita University Hospital
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- Itoh Kunihiko
- Department of Clinical Pharmacology and Genetics, School of Pharmaceutical Sciences, University of Shizuoka
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- Yoshida Keizo
- Department of Psychiatry, Nagoya University Graduate School of Medicine
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- Higuchi Hisashi
- Omagari City Hospital
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- Kamata Mitsuhiro
- Yuri Kumiai General Hospital
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- Takahashi Hitoshi
- Yokote Kosei Hospital
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- Shimizu Tetsuo
- Department of Psychiatry, Akita University School of Medicine
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- Suzuki Toshio
- Department of Pharmaceutical Science, Akita University Hospital
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Abstract
Norepinephrinergic neurotransmission in the central nervous system have a major impact on the symptomatology in major depressive disorder (MDD), and genetic polymorphisms of norepinephrine transporter (NET) have a possibility to be involved in susceptibility to MDD. We investigated the association of the G1287A (rs5569) polymorphism of the NET gene and susceptibility to MDD by comparing 145 major depressive patients with 164 healthy individuals first in a Japanese population. The genotype frequencies in depressed patients and health volunteers of the NET G1287A polymorphism were 52.4% (G/G), 39.3% (G/A) and 8.3% (A/A) in depressed patients, 61.6% (G/G), 29.9% (G/A allele) and 8.5% (A/A) in healthy volunteers, respectively. The allele frequencies in depressed patients and health volunteers of the NET G1287A polymorphism were 72.1% (G allele) and 27.9% (A allele) in depressed patients, 76.5% (G allele) and 23.5% (A allele) in healthy volunteers, respectively. The genotype distribution and allele frequencies were not significantly different between major depressive patients and healthy volunteers. NET G1287A polymorphism appears not to be an important factor in susceptibility to MDD in a Japanese population.
Journal
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- Biological and Pharmaceutical Bulletin
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Biological and Pharmaceutical Bulletin 30 (10), 1996-1998, 2007
The Pharmaceutical Society of Japan
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Details 詳細情報について
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- CRID
- 1390282679601874688
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- NII Article ID
- 110006436394
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- NII Book ID
- AA10885497
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- ISSN
- 13475215
- 09186158
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- NDL BIB ID
- 8919753
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed