High-Frequency Genetic Contents Variations in Clinical Candida albicans Isolates

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  • Yang Feng
    Department of Pharmacology, School of Pharmacy, China Pharmaceutical University
  • Yan Tian-Hua
    Department of Pharmacology, School of Pharmacy, China Pharmaceutical University
  • Rustchenko Elena
    Department of Biochemistry and Biophysics, School of Medicine and Dentistry, University of Rochester Medical School
  • Gao Ping-Hui
    Department of Pharmacology, School of Pharmacy, Second Military Medical University
  • Wang Yan
    Department of Pharmacology, School of Pharmacy, Second Military Medical University
  • Yan Lan
    Department of Pharmacology, School of Pharmacy, Second Military Medical University
  • Cao Ying-Ying
    Department of Pharmacology, School of Pharmacy, Second Military Medical University
  • Wang Qiu-Juan
    Department of Pharmacology, School of Pharmacy, Second Military Medical University
  • Ji Hui
    Department of Pharmacology, School of Pharmacy, China Pharmaceutical University
  • Cao Yong-Bing
    Department of Pharmacology, School of Pharmacy, Second Military Medical University
  • Jiang Yuan-Ying
    Department of Pharmacology, School of Pharmacy, Second Military Medical University

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Genome plasticity is a hallmark of Candida albicans and is believed to be an adaptation strategy. But the extent of such genomic variability is not well investigated. In this study, genetic contents of clinical C. albicans isolates were investigated at whole-genome level with array-based comparative genomic hybridization (array CGH) technology. It was revealed that C. albicans possessed variations of genetic contents, as well as aneuploidy. The variable genes were scattered across the chromosomes, as well clustered in particular regions, including sub-telomeric regions, retrotransposon-insertion sites and a variable region on chromosome 6.

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